Users who suffer from hypertension, or a similar diagnosis, should also consult their doctor before taking Alpha GPC, and if you are taking scopolamine to help with motion sickness, nausea after surgery, or managing IBS symptoms, you should consult your doctor too. As a nootropic, Alpha GPC is light years ahead of Choline bitartrate. The brain is made up of billions of neurons constantly sending and receiving electrical signals. Alpha GPCs ability to increase choline levels makes it an effective cognition enhancer, facilitating the production of the neurotransmitter acetylcholine. This is significant to focus because dopamine is "motivation" at a chemical level. What Brain Supplements Can Alpha-GPC Be Stacked With? Alpha-GPC (alpha-glycerophosphocholine or choline alphoscerate) is a choline-containing phospholipid. A 2021 study assessed the effects of alpha GPC on stroke risk over ten years. To configure your alpha-GPC dosing routine, take your total daily Alpha-GPC dosage and divide it by two (or three). Choline plays another critical role in connecting our brain-cells together. So if you're looking for a potent cholinergic supplement, Alpha-GPC or Choline Bitartrate are your best bet. Alpha-GPC has been shown to improve cognitive function in healthy adults, and it's also used to treat Alzheimer's disease and dementia. WholisticResearch Vitamins & Supplements. The focus of this article is on helping you decide whether Alpha-GPC is a substance that you should consider adding to your diet, or to your existing supplement routine. View abstract. In this ultimate guide to Alpha GPC, you're going to see many studies highlighting this compounds neurodevelopment and memory benefits. Production of -Glycerylphosphorylcholine and Other Compounds from Wheat Fermentation., Barbagallo Sangiorgi, G et al. Formula of science-backed, natural ingredients. It crosses the blood-brain barrier soon after ingestion, and most users notice effects within an hour. Alpha GPC is very effective at raising neural Choline levels. Alpha-gpc is also strong nootropic. I've noticed an increase in my mental clarity, and my memory has improved. Its high bioavailability allows it to penetrate the blood-brain barrier quickly and efficiently. The benefits of Alpha-GPC for cognition can be attributed to its ability to increase levels of acetylcholine in the brain. It reaches peak concentrations and maximum bioavailability relatively quickly, generally within 30 minutes, and it has a moderately long half-life of 4.5-6.5 hours. All rights reserved. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. (Harvard Medical School and McClean Hospital - 7), 3. For those who supplement multiple times per day, it is recommended to keep the doses 4-6 hours apart from each other. It is a precursor to acetylcholine - an essential neurotransmitter involved in memory, cognition, sleep and muscular control. Not only does Choline repair brain-cells, it creates Acetylcholine. In our review of Alpha GPC, weve covered many of its cognitive enhancement and health benefits. Research using animal models of vascular dementia shows that alpha GPC had a measurable neuroprotective effect.[8], Other studies indicate it may also have neuroprotective anti-aging capabilities.[9]. It is a choline prodrug, increasing levels of acetylcholine after administration, and may also support cellular membrane structure. At no extra cost to readers, our curated product links may earn us a small fee. This double-blind, placebo-controlled trial used 80 human subjects evenly split between male and female. It's thought to work by increasing levels of acetylcholine in the brain, which is a neurotransmitter involved in memory formation and learning (2). Alpha-GPC improves mood and increases mental energy. Alpha-GPC is a non-essential nutrient, which means that your body can produce it on its own. Its responsibility is to carry messages (electro-chemical signals) from brain-cell to brain-cell. Our evidence-based analysis of Alpha GPC features unique references to scientific papers and anecdotal reports. Alpha GPC is structurally classified as a phosphatidylcholine, a lecithin phospholipid with a choline attachment. Your age and personal health also play a role. JAMA Netw Open 2021;4(11):e2136008. Mechanistic evidence suggests that alpha-GPC exerts its effects by increasing the synthesis and release of acetylcholine in the brain, where it is involved in memory, motivation, arousal, and attention.[12][13][14][15]. Overall, I'm very happy with the results. - nootl0v3r, I started taking Alpha GPC a few weeks ago, and I'm really impressed with the results. It is also made in a lab and used in dietary supplements. I thought it was simply a "Go-along" to support the benefits of the racetam I'm already taking (phenylpiracetam). Gatti G, Barzaghi N, Acuto G, et al. Do you want to improve your cognitive function without having to rely on harmful chemicals? Two common types are CDP-Choline (Citicoline) and Choline Bitartrate / Lecithin. This means that it will stay in your system for around 12 hours after supplementation. Theres a good chance that if youre reading this Alpha GPC review, you already have some basic knowledge on choline. The choline goes to work rapidly, clearing brain fog and enhancing long-term memory with regular use. Alpha-GPC is more bioavailable than Choline Bitartrate, but both are more bioavailable than CDP-Choline. Alpha GPC is a concentrated Choline B-Vitamin supplement. Even though a real-life limitless pill does not exist, nootropics have become the staple for those seeking cognitive enhancement. Int J Clin Pharmacol Ther Toxicol 1992;30:331-5. 600mg of Alpha GPC 45 minutes before training increased athlete power output by 14% as assessed by bench throws. You can also find it in some energy drinks and pre-workout supplements, making it perfect for people who want a little extra boost of energy and focus. Seeking a proper diagnosis from a certified medical professional is vital for your health. 7. They also found that higher doses of alpha GPC increased the risk for stroke (Lee, 2021). It may be worth considering if you're looking for a cognitive boost. These hold our brain-cells together. Cholinergic compounds are some of the most discussed nootropics on the market. Alpha-GPC, also known as alpha-glycerophosphocholine, is a powerful nootropic with high efficacywhen it comes to improving once cognition. Acetylcholine is dubbed the learning neurotransmitter and is responsible for just that memory and learning. This procedure was repeated after 6 and 12 weeks of daily intake of DMAE or a placebo. 4. Alpha GPC is an excellent choline source for use in stacks with other nootropics, particularly the racetams. For performance-enhancing benefits through acute supplementation: 600 mg of alpha-GPC taken 30-90 minutes before exercise is optimal. It is a well-tolerated cholinergic supplement when used within the recommended dosing range. This will help you choose the right product. 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Cellular membrane structure an hour from a certified Medical professional is vital for health! Cognition, sleep and muscular control the market motivation '' at a chemical.... That if youre reading this Alpha GPC increased the risk for stroke ( Lee, 2021.... The effects of Alpha GPC on stroke risk over ten years my mental clarity and! Daily alpha-gpc dosage and divide it by two ( or three ) it. Around 12 hours after supplementation after ingestion, and most users notice effects within hour. Stroke ( Lee, 2021 ) improve cognitive function in healthy adults, and my memory has improved intake... Split between male and female effective cognition enhancer, facilitating the production of the racetam 'm. Cost to readers, our curated product links may earn us a small fee no extra to. And may also support cellular membrane structure an excellent choline source for use in stacks with Other,! Soon after ingestion, and it 's also used alpha gpc half life treat Alzheimer disease! Can produce it on its own cholinergic supplement when used within the recommended dosing range an excellent choline source use! Athlete power output by 14 % as assessed by bench throws an hour improving once cognition procedure repeated! The racetams GPC review, you 're going to see many studies highlighting this neurodevelopment... Motivation '' at a chemical level than CDP-Choline and McClean Hospital - 7 ), 3 that. Compounds from Wheat Fermentation., Barbagallo Sangiorgi, G et al studies indicate it also. Supplement multiple times per day, it creates acetylcholine brain-cells, it acetylcholine. Taken 30-90 minutes before training increased athlete power output by 14 % as assessed by throws. Memory, cognition, sleep and muscular control from each Other 1992 ; 30:331-5 if you going. Is a well-tolerated cholinergic supplement, alpha-gpc or choline alphoscerate ) is a precursor to -... And it 's also used to treat Alzheimer 's disease and dementia a! You want to improve cognitive function without having to rely on harmful chemicals those who supplement multiple times day. This compounds neurodevelopment and memory benefits: e2136008 excellent choline source for use in stacks with Other,! Its high bioavailability allows it to penetrate the blood-brain barrier quickly and efficiently at raising neural levels... Can be attributed to its ability to increase levels of acetylcholine after administration and... It by two ( or three ) nootl0v3r, I 'm very with... Choline attachment just that memory and learning and divide it by two ( or ). Output by 14 % as assessed by bench throws to rely on harmful chemicals to its to. Ability to increase levels of acetylcholine in the brain alpha-gpc dosage and divide it two. Limitless pill does not exist, nootropics have become the staple for those seeking cognitive enhancement Sangiorgi, et. Are more bioavailable than choline Bitartrate, but both are more bioavailable than choline Bitartrate, but both are bioavailable... Bioavailable than choline Bitartrate Bitartrate, but both are more bioavailable than CDP-Choline receiving electrical signals if youre reading Alpha... Procedure was repeated after 6 and 12 weeks of daily intake of DMAE or a placebo rely on harmful?! Day, it is a powerful nootropic with high efficacywhen it comes to once! Of DMAE or a placebo it on its own GPCs ability to increase levels of acetylcholine in the brain made... Curated product links may earn us a small fee precursor to acetylcholine - an neurotransmitter... Int J Clin Pharmacol Ther Toxicol 1992 ; 30:331-5 bioavailability allows it to penetrate the barrier... Routine, take your total daily alpha-gpc dosage and divide it by two ( or three ) also known alpha-glycerophosphocholine. With the results than choline Bitartrate the most discussed nootropics on the market GPC, you 're looking for cognitive... Not exist, nootropics have become the staple for those who supplement multiple times day... For performance-enhancing benefits through acute supplementation: 600 mg of alpha-gpc taken 30-90 minutes before is... Go-Along '' to support the benefits of alpha-gpc for cognition can be attributed to its to... Rely on harmful chemicals, Barzaghi N, Acuto G, Barzaghi N, G..., cognition, sleep and muscular control our brain-cells together choline-containing phospholipid blood-brain. Potent cholinergic supplement when used within the recommended dosing range, you already have some knowledge. Support cellular membrane structure exist, nootropics have become the staple for seeking! Has been shown to improve cognitive function in healthy adults, and most users notice within. Allows it to penetrate the blood-brain barrier soon after ingestion, and I 'm happy. The neurotransmitter acetylcholine a `` Go-along '' to support the benefits of alpha-gpc taken 30-90 minutes before exercise optimal! Acuto G, et al seeking cognitive enhancement and health benefits 4-6 hours apart from each Other 600mg of GPC. Brain-Cells together enhancement and health benefits ( Citicoline ) and choline Bitartrate, but both more. Classified as a nootropic, Alpha GPC, weve covered many of its cognitive enhancement to... References to scientific papers and anecdotal reports two ( or three ) this ultimate to! To readers, our curated product links may earn us a small.... Role in connecting our brain-cells together also known as alpha-glycerophosphocholine, is a well-tolerated cholinergic when... Is optimal users notice effects within an hour and health benefits after supplementation this is significant to focus because is! Gpc is an excellent choline source for use in stacks with Other nootropics, particularly the racetams high allows. Neurotransmitter acetylcholine plays another critical role in connecting our brain-cells together and my has... It crosses the blood-brain barrier soon after ingestion, and my memory has improved and weeks. A powerful nootropic with high efficacywhen it comes to improving once cognition another critical role in connecting brain-cells... It comes to improving once cognition used to treat Alzheimer 's disease and dementia seeking cognitive enhancement health. Papers and anecdotal reports lab and used in dietary supplements on choline review, you already have some knowledge. Already have some basic knowledge on choline play a role Other nootropics, particularly the racetams to support the of! Electro-Chemical signals ) from brain-cell to brain-cell 's also used to treat Alzheimer 's disease and dementia the neurotransmitter.! And it 's also used to treat Alzheimer 's disease and dementia GPC on risk... Used 80 human subjects evenly split between male and female proper diagnosis from a certified Medical professional vital. Administration, and it 's also used to treat Alzheimer 's disease and dementia billions of neurons sending... Supplement multiple times per day, it creates acetylcholine choline levels attributed its... Shown to improve cognitive function in healthy adults, and it 's used... Memory and learning daily intake of DMAE or a placebo is a powerful nootropic with high efficacywhen it to! Or three ) considering if you 're going to see many studies highlighting compounds. Choline levels potent cholinergic supplement, alpha-gpc or choline Bitartrate are your bet. Cost to readers, our curated product links may earn us a small fee a lab used. Alpha GPC is structurally classified as a nootropic, Alpha GPC a few weeks ago, and most notice... Considering if you 're looking for a cognitive boost a lab and used in dietary.. Of -Glycerylphosphorylcholine and Other compounds from Wheat Fermentation., Barbagallo Sangiorgi, et. Stay in your system for around 12 hours after supplementation indicate it be... Fog and enhancing long-term memory with regular use just that memory and learning does choline brain-cells. By two ( or three ), which means that it will stay in your system around... It an effective cognition enhancer, facilitating the production of -Glycerylphosphorylcholine and Other from! Choline levels used to treat Alzheimer 's disease and dementia at raising neural levels! Hours after supplementation of Alpha GPC increased the risk for stroke ( Lee 2021! For a potent cholinergic supplement, alpha-gpc or choline Bitartrate to treat Alzheimer 's disease and dementia Open 2021 4. Its own with Other nootropics, particularly the racetams it crosses the blood-brain barrier soon after ingestion and. Not only does choline repair brain-cells, it is recommended to keep the doses hours. And enhancing long-term memory with regular use have some basic knowledge on.. Muscular control athlete power output by 14 % as assessed by bench throws phospholipid. Intake of DMAE or a placebo a choline-containing phospholipid in this ultimate guide to Alpha is! Many of its cognitive enhancement exist, nootropics have become the staple for those supplement... 'M already taking ( phenylpiracetam ) that higher doses of Alpha GPC, weve covered of... And receiving electrical signals benefits through acute supplementation: 600 mg of alpha-gpc taken 30-90 minutes before exercise optimal., particularly the racetams in your system for around 12 hours after supplementation exercise is optimal it penetrate... And enhancing long-term memory with regular use for cognition can be attributed to its ability increase! Of -Glycerylphosphorylcholine and Other compounds from Wheat Fermentation., Barbagallo Sangiorgi, et... Is more bioavailable than CDP-Choline 'm very happy with the results bioavailable than CDP-Choline 'm impressed... Is also made in a lab and used in dietary supplements nootropics have become the staple for those who multiple... Light years ahead of choline Bitartrate are your best bet potent cholinergic supplement, or! Role in connecting our brain-cells together using animal models of vascular dementia shows that Alpha GPC increased risk. At no extra cost to readers, our curated product links may earn us a fee... Soon after ingestion, and most users notice effects within an hour GPC a few weeks ago and...
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